Cialis and Levitra Comparison by Rotation Medical
| Cialis | Levitra | |
| Key component | Tadalafil | Vardenafil |
| Drug classification | Phosphodiesterase 5 inhibitor | Phosphodiesterase 5 inhibitor |
| Indication | Erectile dysfunction, pulmonary arterial hypertension, benign prostatic hyperplasia. | Erectile dysfunction, premature ejaculation |
| Prescription drug | YES | YES |
| Influence on ability to operate machines | It is not precisely known whether the drug elicits effect on the capability to drive and operate machinery. However, patients should be aware of their reaction to Cialis before driving or operating complex machines. | It is not precisely known whether the drug enters into the capability to drive and operate machinery. Given that dizziness and abnormal vision events may develop after administering Levitra, patients should take a weighted decision before driving or operating complex machines. |
| Interaction with alcohol | Can be administered with alcohol. | Levitra does not have any significant impact on blood pressure or cardiac rhythm if used together with alcohol. Alcohol does not baffle the pharmacokinetics of Levitra. |
| Special warnings | Cialis might cause an erection to remain for several hours. If left unmanaged, priapism may reduce to the damage to penile tissues, which is fraught with permanent impairment of sexual function. | Vardenafil has vessel-widening properties, which may result in a critical drop in blood pressure. Subjects with established cardiovascular diseases for whom sexual activity is contraindicated must not take Levitra to cure erectile frustration. |
| Action principle | Under sexual excitement, an erection is summoned by an intense penile blood supply, deriving from the expanding of penile arteries and relaxation of the smooth muscles found in the corpus cavernosum. This response occurs by the release of nitric oxide (NO) from nerve endings and endothelial cells, which ultimately activates the production of cyclic guanosine monophosphate (cyclic GMP) in smooth muscle cells. Cyclic GMP makes the unstriated muscles relax, which provides for boosted circulation within the erectile tissue.
The suppression of the PDE5 enzyme by Tadalafil improves an erection by elevating the concentration of cGMP. Sexual excitement is vital to trigger the synthesis of nitric oxide in the penis. Tadalafil will not affect PDE5 if the patient does not feel sexually aroused.
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Identical to Cialis, Levitra involves sexual arousal to produce an effect. The major ingredient of the drug blocks the work of the natural enzyme PDE5 that is responsible for the slackening of erections. Levitra allows an erection to stay long enough to engage in penetrative sexual activity for mutual satisfaction. |
| Contraindications | Hypersensitivity to the active agent or any of the constituents. Tadalafil steps up the hypotensive properties of nitrates. Taking Cialis with any organic nitrate drug is contraindicated. It is risky for people with cardiac disease to take Cialis if they are advised to refrain from sexual activity. The use of Tadalafil must also be avoided in the presence of:
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Hypersensitivity to the active drug or any of the constituents. The use of Vardenafil with nitrates or nitric oxide donors is a contraindication. Individuals who have vision loss events due to NAION cannot take Levitra. Treatment with Vardenafil must be avoided in the presence of:
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| Dose and administration | 20 mg of Cialis should be taken, at least, 16 minutes before expected sexual intercourse, regardless of food intake. Patients can engage in penetrative sexual acts at any time within a 36-hour period after administration without taking an additional dose of Tadalafil. The maximum frequency of use is once/24 hours. | The optimal dose is 10 mg 25–60 minutes before coitus. The drug can also be taken from 4–5 hours to 25 minutes before intimacy. The maximum frequency of use is once/24 hours. Depending on the effectiveness and response, the dose can be decreased to 5 mg per day or increased to not more than 20 mg. |
| Common after effects |
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| Overdose | Overdose symptoms are similar to those seen at common adverse reactions. If overdosed, a patient requires standard supportive measures. | Doses up to 80 mg Vardenafil per day generally do not evoke severe undesirable effects. Higher and more frequent doses of Vardenafil may induce severe back pain. If overdosed, a patient requires standard supportive measures. |
| Interactions | Tadalafil enhances the hypotensive action of nitrates. The use of Tadalafil in patients receiving nitrates is contraindicated. | Vardenafil should not be used by individuals taking nitrate medications, because the co-administration of Vardenafil with any organic nitrates may translate into potentially dangerous hypotension. |
| Duration of action | Tadalafil’s half-life is nearly 17.5 hours. This leads to prolonged effectiveness, which explains why the drug is dubbed “The Weekend Pill”. | The medium terminal-phase elimination half-life of Vardenafil ranges between 4–6 hours. |
Cialis vs Levitra key distinctions
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See also video review about Levitra:
Indications and contraindications of Levitra and Cialis are the same as with other PDE5 inhibitors. Levitra (Vardenafil) has a relatively short effective time compared to Cialis (Tadalafil).
Beyond its primary indication for erectile issues, Vardenafil is also used in the improvement of premature ejaculation, where it may remarkably prolong the time from penetration to ejaculation.
The effect of Levitra usually manifests itself in 30 minutes after intake — but it can take an effect in as little as just 15 minutes. It should be taken nearly an hour before the anticipated intimacy, while Cialis may need up to two hours before starting its action.
Levitra preserves its effectiveness for around five hours, while Cialis lasts for up to 36 hours — that’s seven times longer than Levitra. At the same time, Levitra is less affected by food and alcohol compared to Cialis, so can be administered with meals.
Who is the winner?
Levitra is a popular pick for those who need a quick-acting ED cure that preserves its effectiveness for nearly five hours. It is a good variant to consider if you do not have sex too frequently.
Cialis is great for patients looking for a treatment that can back up the sexual confidence for about two days in a row. The drug is a wise option for subjects leading an active and regular sexual life.
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